Preventive Effect of Treatment With Estradiol Vaginal Tablets on Recurrent Urinary Tract Infections in Post-menopausal Women

Preventive Effect of Treatment With Estradiol Vaginal Tablets on Recurrent Urinary Tract Infections in Post-menopausal Women (RUTI) in Post-menopausal Women With Signs of Urogenital Ageing (UGA)

Status

Terminated

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00560924

Enrollment

Registered

2007-11-20

Start date

2003-03-21

Completion date

2004-03-17

Last updated

2017-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Menopause, Urinary Infections

Brief summary

This trial is conducted in Europe. The aim of this trial is to investigate the preventive effect of treatment with estradiol vaginal tablets on recurrent urinary tract infections (RUTI) in post-menopausal women with signs of urogenital ageing (UGA).

Interventions

DRUGestradiol, 25 mcg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Inclusion criteria

* Post-menopausal woman with Urogenital ageing (UGA) * Recurrent urinary tract infections defined as three or more urinary tract infections within the past twelve months

Exclusion criteria

* Known or suspected allergy to trial product or related products * Present UTI * History of RUTI during fertile period of life

Design outcomes

Primary

Measure	Time frame
Time to first symptom of urinary tract infection (UTI)	—

Secondary

Measure	Time frame
Number of urinary tract infection (UTI)	During the 12 months of treatment

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026