Efficacy Study of Intramuscular or Intracoronary Injection of Autologous Bone Marrow Cells to Treat Scarred Myocardium

Efficacy of the Mode of Delivery of Autologous Bone Marrow Cells Into Heart Scar Muscle for the Recovery of Contractile Function

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00560742

Enrollment

Registered

2007-11-20

Start date

2002-11-30

Completion date

2007-07-31

Last updated

2007-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Marrow Cells, Myocardial Infarct

Brief summary

The purpose of this study is to determine whether the administration of patient's own bone marrow cells into scar areas of the heart, can improve the contractile function of these areas.

Interventions

PROCEDUREControl

Coronary artery bypass grafting without bone marrow cells injection

PROCEDUREIntramuscular administration of bone marrow cells

Coronary artery bypass grafting, and intramuscular administration of bone marrow cells into myocardial scar

PROCEDUREIntracoronary administration of bone marrow cells

Coronary artery bypass grafting, and intracoronary administration of bone marrow cells into myocardial scar

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients undergoing elective CABG * chronic irreversible myocardial scar * coronary vessel supplying the scar must be amenable to bypass grafting

Exclusion criteria

* significant valvular heart diseases * major organ failures, eg. heart, liver, renal etc * pre-existing bone marrow conditions

Design outcomes

Primary

Measure	Time frame
Contractile function of treated scar areas	6 months

Secondary

Measure	Time frame
Global left ventricular functions	6 months

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026