Atherosclerosis, Intermittent Claudication
Conditions
Keywords
Magnetic resonance, whole body, angiography, venous compression, MRI
Brief summary
To investigate the diagnostic performance of whole body magnetic resonance angiography (WB-MRA) using subsystolic venous compression of the thigh.
Detailed description
WB-MRA is an examination that can evaluate the arteries from head to feet. Timing of the injected bolus of contrast medium can be difficult, especially in the legs. As the result of the WB-MRA depends on the contrast medium only being in the arteries at the time of examination, the use of venous compression is a possible way of overcoming the problem of early venous filling, that can hamper the diagnostic value of the examination. Venous compression is performed with a blod pressure cuff around the thighs. It is inflated to subsystolic pressure (45 mm Hg). This elevated pressure leads to filling of the lower leg arteries and late venous filling.
Interventions
Magnetic resonance angiography using a paramagnetic contrast agent.Venous compression performed with a blood-pressure cuff around both thighs.
Sponsors
Copenhagen University Hospital at Herlev
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Symptomatic lower extremity ischemia (claudication, ischemic wounds) * Referred to digital subtraction angiography (DSA)
Exclusion criteria
* Renal insufficiency (GFR \< 30 ml/min) * Contra-indications for MRI-examination (claustrophobia, metal-implants, pacemaker) * Dementia * Pregnancy/lactation * Allergy to gadolinium based MRI contrast agents * Acute disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vascular diagnostic quality on the WB-MRA. Degree of arterial stenosis on the WB-MRA | 1 month |
Countries
Denmark
Outcome results
None listed