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Continuous Positive Airway Pressure on Tuberculosis Pleural Effusion

Effect of Continuous Positive Airway Pressure on Fluid Absorption Among Patients With Pleural Effusion Due to Tuberculosis

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00560521
Enrollment
20
Registered
2007-11-19
Start date
2005-03-31
Completion date
2007-03-31
Last updated
2007-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pleural Effusion, Tuberculosis

Keywords

CPAP, Tuberculosis, Pleural effusion, Physiotherapy

Brief summary

Tuberculosis (TB) remains as an important public health problem worldwide. Pleural tuberculosis is the most prevalent form of extrapulmonary presentation in immunocompetent patients. The volume of effusion in the pleural space of patients with pleural TB may cause complications like restrictive ventilator lung functional disturb and/or pleural thickening. The respiratory physiotherapy can be adjuvant on treatment of pleural effusion tuberculosis throughout of various treatment technique. The Continuous positive airway pressure (CPAP) is utilized in various pathologic, this improves lung mechanics by recruiting atelectatic alveoli, improving pulmonary compliance, and reducing the work of breathing. The aim of this study is to determine the effect of CPAP on fluid absorption among patients with pleural effusion due tuberculosis.

Detailed description

This randomized and controlled trial compared the reduction of the pleural effusion volume of the group of patients using the anti-TB standard regimen to that using the anti-TB standard regimen AND adjuvant treatment of physical therapy during four weeks. * Control group: The patients received rifampicin, isoniazid and pyrazinamide daily(anti-TB standard regimen) * Interventional group: The patients received anti-tb standard regime and Continuous Positive Airway Pressure (CPAP) 3 times a week for 30 minutes with positive expiratory end pressure of 10 cmH2O. Evaluation of the pleural effusion size: a helicoidal thoracic computed tomography (CT) was carried out in all patients enrolled. The valuation was conducted by two radiologists blinded for the treatment used, specifically trained for the purpose of the study.

Interventions

BEHAVIORALCPAP

Frequency of three times a week, using a positive end expiratory pressure (PEEP) of 10 mmH2O for 30 minutes for four weeks.

Sponsors

Universidade Federal do Rio de Janeiro
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Confirmed diagnosis of pleural tuberculosis. * Patients 18 years of age and older.

Exclusion criteria

* Be under previous treatment of respiratory physiotherapy. * Irregular use or abandonment of the anti-TB standard regimen. * To fail one or more physiotherapy section. * To fail one or more radiological evaluation.

Design outcomes

Primary

MeasureTime frame
Evaluate of pleural effusion volumeone month

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 1, 2026