Acute Pancreatitis, Major Abdominal Surgery, Neurological Diseases, Pneumopathy
Conditions
Keywords
ICU patients
Brief summary
Comparison of metabolic and nutritional effects of an enteral immune enhancing diet with those of a standard polymeric one, in ICU patients
Interventions
DIETARY_SUPPLEMENTCrucial (enteral tube feeding)
Evaluation of new enteral product, Crucial, in ICU patients
Sponsors
Société des Produits Nestlé (SPN)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
* 18\<age\<89, ASA score\<4 , SAPS II score\>10 * requiring the administration of an exclusive tube feeding nutrition during 7 days and beginning at the latest in the three days following the aggression * ICU patients hospitalized for: * neurologic affections * pneumopathy * major abdominal surgery or serious acute pancreatitis * written informed consent
Exclusion criteria
* pregnancy or breast feeding * immunosuppressive therapy * radiotherapy or chemotherapy in the last six month * uncontrolled septic choc * auto-immune disease * hepatic,renal or digestive insufficiency * hyperlipidemia * diabetes mellitus type 1 * digestive malabsorption * life threatening situation * treatments with growing hormone, glutamine or its metabolites or precursors such as ornithine alpha keto glutarate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation of Glutamine after 90 min of enteral product administration | J5 |
Secondary
| Measure | Time frame |
|---|---|
| Nutritional parameters, immunologic parameters, functionality renal, Biological marker of oxidative stress | J1, J5, J8 |
| Tolerance | Daily until J8 |
Countries
France
Outcome results
None listed