Prevention of Acute Mountain Sickness by Intermittent Hypoxia

Prevention of Acute Mountain Sickness by Sleeping at Simulated Altitude (Normobaric Hypoxia)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00559832

Enrollment

Registered

2007-11-16

Start date

2006-03-31

Completion date

2007-07-31

Last updated

2007-11-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Mountain Sickness

Keywords

acute mountain sickness, intermittent hypoxia, acclimatization

Brief summary

Acclimatization by mountaineering prior to high altitude sojourns have shown to be effective in prevention of acute mountain sickness (AMS). The aim of this study is to investigate whether intermittent exposure to normobaric hypoxia during sleep is also effective to prevent AMS.

Interventions

OTHERHypoxic Exposure

Sleeping in normobaric hypoxia for 14 nights at altitudes from 2500 - 3300 m prior to one night at 4500 m

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE

Eligibility

Sex/Gender

MALE

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy

Exclusion criteria

* Altitude exposure above 2000 m 8 weeks prior or during the study

Design outcomes

Primary

Measure	Time frame
incidence of acute mountain sickness	during one night at 4500 m

Secondary

Measure	Time frame
Sleep quality	during one night at altitude
ventilatory acclimatization	during one night at altitude

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026