Colorectal Cancer
Conditions
Keywords
stage IV colon cancer, recurrent colon cancer, stage IV rectal cancer, recurrent rectal cancer
Brief summary
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving cetuximab together with combination chemotherapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving cetuximab together with combination chemotherapy works in treating patients with advanced or metastatic colorectal cancer.
Detailed description
OBJECTIVES: Primary * Improve hematologic and gastrointestinal tolerance to cetuximab and irinotecan hydrochloride, fluorouracil, and leucovorin calcium (FOLFIRI) in patients with advanced or metastatic colorectal cancer. Secondary * Increase the effectiveness of this regimen by intensifying the treatment. * Specify the constitutional genetic and genomic tumor parameters that could interfere with and predict the toxicity and/or antitumor efficacy of this regimen. * Assess the time to progression. OUTLINE: This is a multicenter study. Patients receive irinotecan hydrochloride IV over 90 minutes, leucovorin calcium IV over 2 hours, and cetuximab IV over 1-2 hours on day 1. Patients also receive fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 2 weeks in the absence of disease progression or unacceptable toxicity. Pharmacokinetic and pharmacogenetic studies are also conducted.
Interventions
DRUGleucovorin calcium
OTHERpharmacological study
BIOLOGICALcetuximab
DRUGfluorouracil
DRUGirinotecan hydrochloride
Sponsors
Institut Cancerologie de l'Ouest
Study design
Allocation
NON_RANDOMIZED
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Histologically confirmed colorectal cancer * Advanced or metastatic disease * Scheduled to receive first- or second-line therapy for metastatic disease * No cerebral metastases or symptomatic or uncontrolled meningeal disease PATIENT CHARACTERISTICS: * WHO performance status 0-2 * ANC ≥ 2,000/mm\^3 * Platelet count ≥ 100,000/mm\^3 * Total bilirubin ≤ 2 times upper limit of normal (ULN) * AST and ALT ≤ 3 times ULN * Alkaline phosphatase ≤ 5 times ULN * Not pregnant or nursing * Fertile patients must use effective contraception * No intestinal blockage * No complete dihydropyrimidine dehydrogenase deficiency * No chronic inflammatory disease of the colon * No other cancer except for nonmelanoma skin cancer or curatively treated carcinoma of the cervix or breast * No other severe condition, or condition that is likely to worsen, including any of the following: * Unstable heart disease * Myocardial infarction within the past 6 months * Active uncontrolled infection * No contraindication to atropine PRIOR CONCURRENT THERAPY: * See Disease Characteristics * Recovered from prior anticancer therapy * More than 4 weeks since prior and no other concurrent investigational therapy * Prior adjuvant chemotherapy allowed * No prior fluorouracil or irinotecan hydrochloride * No other concurrent anticancer therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of hematologic and gastrointestinal tolerance to therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Efficacy | — |
| Genetic and genomic tumor parameters that could interfere with and predict the toxicity and/or antitumor efficacy of therapy | — |
| Time to progression | — |
Countries
France
Outcome results
None listed