Proteomics Analysis for Recognition of Acute Cellular Rejection After Lung Transplantation

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00558597

Enrollment

Registered

2007-11-15

Start date

2008-03-31

Completion date

2011-12-31

Last updated

2011-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Transplantation, Rejection

Keywords

Proteomics, Lung Transplantation

Brief summary

In patients with acute rejection after lung transplantation the peptide profile in broncho-alveolar lavage (BAL) and urine should be compared in order to identify a paradigm that allows an non-invasive rejection therapy.

Detailed description

Goal of the study is the establishment of biomarkers for early diagnosis of acute rejection, followed by a late validation of the paradigm with prospectively collected samples, which will be examined blinded.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients with stable graft function * Patients with acute rejection

Exclusion criteria

* Acute infection * BOS

Countries

Germany

Contacts

Primary ContactJens Gottlieb, Dr. med.

gottlieb.jens@mh-hannover.de+49-511-5320

Backup ContactIsabelle Bodmann

bodmann.isabelle@mh-hannover.de+49-511-5320

Outcome results