Systemic, Intrapulmonary and Pleural Inflammatory Reaction in Patients Undergoing Thoracic Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00558350

Enrollment

Registered

2007-11-14

Start date

2007-04-30

Completion date

2011-06-30

Last updated

2012-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Neoplasms

Keywords

lobectomy, inflammatory reaction, intrapulmonary, intrapleural

Brief summary

Inflammatory reaction in different compartments of the body may have a negative effect on outcome. This study assesses the inflammatory reaction systemically, intrapulmonary and intrapleural by measuring different cytokines. Patients with lung cancer undergoing lobectomy or segmentectomy are included in the study. Hypothesis: The inflammatory reaction in the pleural space is high compared to the systemic and intrapulmonary ones.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 90 Years

Healthy volunteers

Inclusion criteria

* elective lobectomy * elective segmentectomy * 20-90 years * informed consent given

Exclusion criteria

* emergency operations * pneumonectomy

Design outcomes

Primary

Measure	Time frame
Cytokine levels in blood, bronchial lavage fluid and pleural fluid	2 years
Correlation between cytokine levels and pulmonary morbidity	2 years

Secondary

Measure	Time frame
Comparison of this collective with transthoracic esophagectomies and evaluation of the inflammatory reactions (esophageal collective registered:NCT00512265)	4 years

Countries

Switzerland

Outcome results