Primary Anatomical Versus Primary Electrophysiological Approach in Circumferential Pulmonary Vein Ablation

Circumferential Pulmonary Vein Ablation in Paroxysmal Atrial Fibrillation: Randomized Comparison Between a Primary Anatomical Versus a Primary Electrophysiological Approach

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00556595

Acronym

CPVA-PAF

Enrollment

200

Registered

2007-11-12

Start date

2007-11-30

Completion date

2008-12-31

Last updated

2007-11-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paroxysmal Atrial Fibrillation

Keywords

atrial fibrillation, paroxysmal, symptomatic, drug-refractory

Brief summary

Randomized comparison between 2 techniques of circumferential pulmonary vein ablation in paroxysmal atrial fibrillation: Primary anatomical ablation with secondary closure of possible electrical gaps versus primary electrophysiological ablation at the sites of atrio-venous electrical breakthroughs with secondary circumferential ablation around the pulmonary vein orifice

Interventions

PROCEDUREprimary electrophysiological approach

primary ablation of atrio-venous breakthrough sites followed by circumferential ablation around pulmonary vein orifice

PROCEDUREprimary anatomical approach

primary circumferential ablation around the pulmonary vein orifice followed by ablation of possible conduction gaps

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* paroxysmal atrial fibrillation * age over 18 years

Exclusion criteria

* persistent atrial fibrillation * reversible cause of atrial fibrillation * inability to comply with follow-up

Design outcomes

Primary

Measure	Time frame
Freedom from atrial tachyarrhythmias at 6-months follow-up	6 months

Secondary

Measure	Time frame
Comparison of procedural characteristics (duration, fluoroscopy time, ablation time, ablation energy, complications)	6 months

Contacts

Primary ContactLars M Lickfett, MD

lars.lickfett@ukb.uni-bonn.de*49-228-287-16670

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026