Subjective Tinnitus
Conditions
Keywords
tinnitus, gabapentin
Brief summary
The purpose of this study is to determine wether Gabapentin which is useful for treating neuropathic pains, is effective on idiopathic subjective tinnitus.
Detailed description
Tinnitus is the perception of sound in the absence of acoustic stimulation. It can be subjective or objective. . Despite numerous researches,no effective treatment for people who suffer from tinnitus has yet been stablished. As there are many evidences suggesting that loss of inhibition in the central nervous system may be responsible for many aspects of auditory dysfunction,including tinnitus; and as Gabapentin (Neurontin), a gama-aminobutyric acid (GABA) analogue, is an effective medication in conditions where inhibition in the CNS is impaired; we guess that Gabapentin might be useful for treating idiopathic subjective tinnitus.
Interventions
DRUGGabapentin
Gabapentin, 600 mg bid for the first two weeks, increased to a maximum dose of 1800 mg per day during the next 6 weeks if necessary.
DRUGplacebo
placebo is given with the same definition as Gabapentin
Sponsors
Islamic Azad University of Mashhad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* patients with subjective idiopathic tinnitus
Exclusion criteria
* tinnitus with known underlying cause * pregnant women and patients younger than 18 or older than 75 years * patients with impaired renal function
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in the sensation of Tinnitus by the patient or complete resolution of tinnitus;by the patient's scoring it from one to ten, before and after prescribing Gabapentin. | two months |
Secondary
| Measure | Time frame |
|---|---|
| Relieve of complications of tinnitus, such as sleep difficulties. | two months |
Countries
Iran
Outcome results
None listed