Fructose Malabsorption, Irritable Bowel Syndrome
Conditions
Keywords
fructose, Irritable bowel syndrome, malabsorption, Glut5 transporter gene
Brief summary
Different published studies has shown a possible co-variation between leakage of fructose to the great bowel and exacerbation of irritable bowel syndrome (IBS) symptoms. The aim of the FINN trial is to study the role of fructose malabsorption in patients with IBS in order to evaluate different diagnostic criteria for fructose malabsorption and at the same time study the effect of diet treatment in this cohort of patients and estimate the prevalence of fructose malabsorption.
Interventions
BEHAVIORALdiet restriction
each meal should contain less than 2 gm fructose
Sponsors
Nordlandssykehuset HF
University Hospital of North Norway
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* IBS patients satisfying ROME 2 diagnostic criteria
Exclusion criteria
* Seriously ill * Organic abdominal disease * Other functional bowel disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score og specific abdominal complaints.SGA score of relief related to abdominal complaints. | 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Estimate sensitivity,specificity,negative and positive predictive value using 50 gm fructose in breath test.Validate questionary for intolerance.Validate VAS in judging changes in abdominal complaint.Examine polymorphism i Glut5 transporter gene. | 12 weeks |
Countries
Norway
Outcome results
None listed