Coronary Artery Disease
Conditions
Brief summary
A pilot study of 15 subjects will be completed to determine whether acute consumption of cranberry juice has an effect on endothelial function. We will then complete a randomized, double blind, placebo controlled crossover study designed to investigate the effects of cranberry juice consumption on endothelial function. Participants (n=40) will drink 480 ml of double strength cranberry juice or a similar appearing and tasting placebo per day for four weeks. After a two week rest period, they will cross over to the other beverage. We will examine endothelial function before and after each of the two treatment periods. The study will provide information about the chronic vascular effects of cranberry juice.
Interventions
DIETARY_SUPPLEMENTCranberry juice
480 ml of double strength cranberry juice daily for four weeks
Sponsors
Boston University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Coronary artery disease
Exclusion criteria
* Pregnant and lactating women * Clinical history of other major illness including end-stage cancer, renal failure, hepatic failure, gastrointestinal disorders that may impair absorption, or other conditions that in the opinion of the principal investigator make a clinical study inappropriate * Treatment with an investigational new drug within the last 30 days * History of a psychological illness or condition such as to interfere with the subject's ability to understand the requirements of the study. * Treatment with Vitamin E, Vitamin C, beta carotene, lipoic acid, or other food or herbal supplements within 2 weeks of enrollment (subjects taking multivitamins or other forms of vitamin E and C in doses that do not exceed two times the RDA will not be excluded).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brachial artery flow-mediated dilation | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Carotid-femoral pulse wave velocity | 1 month |
| Markers of inflammation | 1 month |
| Serum anthocyanins | 1 month |
Countries
United States
Outcome results
None listed