Bladder Cancer
Conditions
Keywords
stage 0 bladder cancer, stage I bladder cancer, transitional cell carcinoma of the bladder
Brief summary
RATIONALE: Learning about the long-term effects of dietary, lifestyle, and environmental factors on the risk of cancer progression and recurrence may help the study of bladder cancer in the future. PURPOSE: This clinical trial is studying how dietary, lifestyle, and environmental factors affect patients with early-stage bladder cancer.
Detailed description
OBJECTIVES: * To examine if common and potentially modifiable dietary, lifestyle, and environmental exposures affect the risk of recurrence and progression in bladder cancer. OUTLINE: This is a multicenter study. Detailed information will be collected about the patients' lifestyle and their exposure to risk factors associated with bladder cancer using semi-structured questionnaires. A baseline questionnaire will be administered at the time of diagnosis and will collect information about socio-demographics, environmental exposures, medical history, diet, health-related quality of life, and social support. Further questionnaires will be administered at regular follow-up visits to capture information relating to changes in exposure. A postal questionnaire will be used to collect historical information that may require the patient to check records or consult family or friends. Patients will also be asked to keep a 1-week food, fluid, and micturition diary. Patients continue to complete questionnaires at 3 months and then annually for up to 5 years. Peer Reviewed and Funded or Endorsed by Cancer Research UK.
Interventions
PROCEDUREmedical chart review
PROCEDUREquestionnaire administration
PROCEDUREstudy of socioeconomic and demographic variables
Sponsors
University of Birmingham
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: Inclusion criteria: * Enrolled on parent protocol CRUK-BCPP-2005-01 * Bladder lesion with cystoscopic characteristics compatible with urothelial cancer or transitional cell carcinoma * Histologically proven urothelial cancer meeting one of the following criteria: * Stage Ta (WHO grade 2/3, or grade 1 tumors that are either multifocal or \> 3 cm in size) * Stage T1 (any grade) * Stage Tis
Exclusion criteria
* Previous diagnosis of cancer of the urethra, bladder, ureter, or renal pelvis within the 10 years prior to current diagnosis PATIENT CHARACTERISTICS: Inclusion criteria: * Fit for cystoscopy and surgical biopsy/resection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence at 5 years | — |
| Progression at 5 years | — |
Countries
United Kingdom
Outcome results
None listed