Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00552487

Enrollment

Registered

2007-11-02

Start date

2005-10-31

Completion date

2006-07-31

Last updated

2007-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adrenal Insufficiency, Hashimoto Disease

Keywords

isolated ACTH deficiency, Hashimoto disease, Hashimoto thyroiditis, autoimmune thyroiditis

Brief summary

The purpose of this study is to determine whether patients with Hashimoto thyroiditis and impaired well-being may have a partial secondary adrenocortical insufficiency.

Detailed description

Many patients with Hashimoto thyroiditis who are correctly substituted with thyroid hormones have an impaired well-being. in some people an isolated ACTH deficiency was found. In this study a 1 µg ACTH test is performed to evaluate the adrenocortical function.

Interventions

DRUGsynacthen

1 µg synacthen in the vein

Study design

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Hashimoto thyroiditis euthyreot thyroid function with levothyroxin therapy written informed consent

Exclusion criteria

* • hypothyroidism of other origin * pregnancy and lactation * oral contraception * glucocorticoid therapy during the last 2 months * History of malignancy or chronic infections (Hepatitis, HIV)

Design outcomes

Primary

Measure	Time frame
serum cortisol-peak 30 min after ACTH-stimulation	30 minutes

Secondary

Measure	Time frame
serum DHEA-peak 30 min. after ACTH-stimulation,DHEA-S, ACTH	30 minutes

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026