Immune Response to Influenza Vaccination

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00551837

Enrollment

Registered

2007-10-31

Start date

2006-11-30

Completion date

2008-05-31

Last updated

2017-10-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease, Solid Organ Transplantation

Keywords

Lung Transplantation, Kidney Transplnatation, Chroinic Kidney Disease, Influenza

Brief summary

The purpose of this study is to evaluate the immune response to a routine influenza vaccination. Influenza vaccination is given as part of routine standard of care in these individuals and is not part of the study protocol. The study will evaluate for a change in response to common antigens over time after influenza vaccination to determine if changes are related to the development of chronic rejection after solid-organ transplantation. We hypothesize that the influenza vaccine contributes to the alloreactivity of T cells verses common HLA types in the donor pool.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Transplant recipients (lung or kidney) 18 years or older, more than 3 months after transplantation * Transplant candidates (kidney) 18 years or older, to recieve influenza vaccination * Healthy volunteers to receive influenza vaccination

Exclusion criteria

* Under 18 years of age * Pregnant * Medical contraindication for vaccine * Transplant recipients receiving acute rejection therapy within one month * Healthy volunteers with autoimmune disease or medications to mediate immune function * Receipt of live, attenuated influenza vaccine, instead of injectable vaccine

Outcome results