Coronary Artery Disease
Conditions
Brief summary
The study is a double blind 2x2 factorial study. Patients with coronary disease will be randomly be assigned to L-arginine (9 g/day), creatine 21 g/d, both, or neither dietary supplement. The function of the endothelium will be tested using ultrasound before and after each treatment. These studies will help us understand why the endothelium is abnormal in patients with coronary artery disease and how L-arginine is acting on endothelial function.
Interventions
DIETARY_SUPPLEMENTCreatine
Creatine 21 g daily
DIETARY_SUPPLEMENTL-arginine and creatine
L-arginine
DIETARY_SUPPLEMENTl-arginine
l-arginine 9 g daily
DIETARY_SUPPLEMENTplacebo, double
placebo
Sponsors
Boston University
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Coronary artery disease
Exclusion criteria
* Pregnancy * Creatine use within one month of study * L-arginine use within one month of study * Change in dose or initiation of lipid lowering therapy, aspirin therapy, or angiotensin converting enzyme therapy within one month of study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Brachial artery flow-mediated dilation | 5 days |
Secondary
| Measure | Time frame |
|---|---|
| serum arginine, creatine, creatinine, homocysteine | 5 days |
Outcome results
None listed