The Association of Genetic Polymorphisms With Statin-Induced Myopathy.

Rhabdomyolysis, Myopathy

muscle disorder, statins, creatine kinase

To observe not only the distribution of single nucleotide polymorphism in genes related with pharmacodynamic and pharmacokinetics alteration of statins but also to analyze the correlation between these SNPs and the incidence of statins-induced myopathy.

Statins are widely prescribed for the patients with hypercholesterolemia. Though their efficacy in preventing cardiovascular events has been shown by a large number of clinical trials, myotoxic side effects including myopathy or even more severe,rhabdomyolysis are associated with the use of statins. Because the incidence of myopathy is various among individuals,polymorphism in genes is supposed to be the main factor. Due to single nucleotide polymorphism in related genes,level of uptake, clearance and metabolism of statins can be seriously different among individuals resulting in various occurrence of myopathy. Therefore, analytical study in association between SNP of statins-related genes and the incidence of myopathy is such a critical research which can be applied into clinical fields.

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Taiwan