Relationship Between Microcirculatory Flow Alterations and Tissue Metabolism

Correlation Between Microcirculatory Flow and Rectal Anaerobe Cellular CO2 Production in Patients After Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00547859

Enrollment

Registered

2007-10-23

Start date

2007-11-30

Completion date

2008-11-30

Last updated

2008-11-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery

Keywords

microcirculation, cardiac surgery, metabolism, capnometry

Brief summary

The purpose of this study is to correlate microcirculatory flow and rectal anaerobe cellular CO2 production in patients after cardiac surgery. The hypothesis is that such a correlation exists.

Detailed description

Sidestream Darkfield imaging is used to determine rectal microcirculatory flow in patients after postoperative cardiac surgery. At the same time PCO2 gap is established by monitoring rectal CO2 (tonometry) and arterial CO2 After initial enrollment and first analysis we also includes a control group with equal inclusion criteria for sublingual SDF imaging.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* cardiac surgery * informed consent * age \> 18

Exclusion criteria

* pregnancy * off pump procedure * rectal fecal contamination

Design outcomes

Primary

Measure	Time frame
Relation between MFI (by SDF) and capno	6 months

Secondary

Measure	Time frame
Relevance of changes in flow and metabolism	6 months

Countries

Netherlands

Outcome results