Functional Organization of Somatosensory Responses in the Secondary Somatosensitive Area and Insula

Functional Organization of Somatosensory Responses in the Secondary Somatosensitive Area (SII) and Insula : an fMRI Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00542906

Enrollment

Registered

2007-10-12

Start date

2007-10-31

Completion date

2008-04-30

Last updated

2009-06-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

healthy volunteers, Somatosensory stimuli, fMRI, second somatosensory area, insular cortex, functional anatomy

Brief summary

The implication of the second somatosensory area (SII) and the insular cortex in the processing of somatosensory inputs is now well established. However the functional anatomy of these areas hidden in the depth of the sylvian scissure remain mostly unknown. The aim of this fMRI study is to determine the functional cartography of SII and insula. The localization of responses to different somatosensory stimuli (slight touch, warm, cold, heat pain and arthrokinesia) applied on the left hand of 25 healthy volunteers, will be compared.

Detailed description

Aims : Demonstrate that localization of the several types of somatosensory stimuli is different into SII and into insula. If possible, we'll determine a functional cartography of these areas.

Interventions

OTHERlocalization

localization of the several types of somatosensory stimuli

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* 25 healthy volunteers will be included ranging in age from 18 to 50 years * contraception needed for women * right handed * All the subjects have to give their written informed consent.

Exclusion criteria

* pregnancy * neurological or psychiatric disease * drugs taken \<12h before fMRI * contra-indications to fMRI : pacemaker, clip, metallic device * Refusing to be informed of the presence of a cerebral abnormality, detected during MRI.

Design outcomes

Primary

Measure	Time frame
Comparison of euclidian distances between the centroids of clusters activations for the different types of stimulations into SII and insula.	one day

Secondary

Measure	Time frame
Determine the Talairach coordinates of the centroids of clusters of activations for the different types of somatosensory stimuli into SII and insula	one day

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026