Pregnancy Rate
Conditions
Keywords
GnRH analog, IVF, infertility, frozen-thawed embryos
Brief summary
Supraphysiological hormonal stimulation enables collecting many oocytes in an In-Vitro Fertilization treatment, but may have a negative effect on uterine function and contribute the fact that the majority of preembryos placed in the uterus fail to implant. Several medical agents were shown to be beneficial when given in the luteal phase of an IVF cycle, but the optimal regimen has not been yet determined. In 2006, a European group reported that addition of GnRH analog (Decapeptyl) as luteal support in IVF cycle significantly improved pregnancy and delivery rates. It is not known whether this positive effect influences the corpus luteum, embryo or the uterus. The researchers sought to evaluate the effect of GnRH administration as luteal support in frozen-thaws IVF cycle.
Interventions
DRUGDecapeptyl 0.1 mg after embryo transfer
Decapeptyl 0.1 mg (Ferring, Kiel, Germany) 3 days following embryo transfer
Sponsors
Shaare Zedek Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
IVF patients transfer of a minimum of two medium-quality thawed embryos in IVF
Exclusion criteria
1. Two or more fresh IVF embryo transfer or three or more thawed embryos transfer with no pregnancy. 2. maximal endometrial thickness \< 6 mm or intracavitary fluid at the time of embryo transfer on previous cycles 3. Untreated hydrosalpinges 4. intracavitary mass 5. submucous myoma 6. known allergy to one of medical agents used in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnancy and delivery rates | — |
Countries
Israel
Contacts
Primary ContactAvi Tsafrir, MD
Backup ContactEhud Margalioth, MD
Outcome results
None listed