Port-Wine Stain
Conditions
Brief summary
Lasers are the treatment modality of choice for Port Wine Stain birthmarks.The epidermis is not totally spared due to partial absorption of energy therein by melanin that presents an optical barrier through which the light must pass to reach the underlying blood vessels. Absorption of laser energy by melanin causes localized heating in the epidermis, which may, if not controlled, produce permanent complications such as hypertrophic scarring or dyspigmentation.
Detailed description
The researchers want to establish a correlation between non-invasive skin temperature measurements and the minimum laser energy during skin laser treatment using cryogen spray cooling. This study would eliminate the need for test pulses to estimate the safe and acceptable radiant exposure prior to laser treatment.
Interventions
PROCEDUREcooling spray during laser treatment
skin temperature measurement
Sponsors
Beckman Laser Institute University of California Irvine
Candela Corporation
University of California, Irvine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
7 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* 7 years of age and older with diagnosis of port wine stain birthmark * 18 years of age and older with no port wine stain * non-pregnant women * apparent good health
Exclusion criteria
* age less than 7 years old * pregnant women * history of photodermatoses or skin cancer * current use of photosensitizing drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| skin temperature during laser treatment | 90 days |
Countries
United States
Outcome results
None listed