Effect of Mental Stress on Platelet Function

Effect of Mental Stress on Platelet Function in Healthy Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00538707

Enrollment

Registered

2007-10-03

Start date

2007-09-30

Completion date

2009-12-31

Last updated

2010-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental Stress

Keywords

mental stress, platelet adhesion, platelet function, catecholamines

Brief summary

The aim of the project is to study the acute and chronic effect of mental stress on platelet adhesion and aggregation in two population composed of normal subjects at different ages

Detailed description

Psychological stress is an important cardiovascular risk factor. Activation of platelets plays an important role in atherosclerosis development and it could be one of the mechanisms linking psychological stress and cardiovascular diseases. We plan to include 32 healthy subjects. (16 in every group). One group with subjects at age 20 - 49 and the other group with subjects at age 50 - 70 years. The aim of the study will be to assess the acute and chronic effect of a standard short mental stress (2-minute Bondet Test) on platelet function and of the level of endothelin-1, catecholamines and cortisol. We plan to evaluate if age may play a role in the effect of psychological stress on platelet function.

Interventions

BEHAVIORAL2-minute Bondet test

2-minute Bondet test

Study design

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy subjects between 20 - 70 years of age * written informed consent * no evidence of diseases

Exclusion criteria

* pregnancy * oral contraceptives * smoking * use of aspirin or NSAIDs within the last week * use of benzodiazepines within the last week * Alcohol or drug abuse * participation in another study within the last month

Design outcomes

Primary

Measure	Time frame
Evaluation of platelet function (shear stress dependent platelet adhesion and aggregation) before and after mental stress	60 minutes

Secondary

Measure	Time frame
Evaluation of the plasma level of endothelin, catecholamines and salivary cortisol level before and after mental stress	60 minutes

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026