Hypertension, Pulmonary
Conditions
Keywords
pulmonary hypertension, simvastatin, advanced pulmonary hypertension secondary to congenital heart disease, advanced pulmonary hypertension secondary to chronic pulmonary embolism
Brief summary
we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
Detailed description
advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism.It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
Interventions
DRUGsimvastatin
medication with simvastation on the dosage of 40mg per day before the operation and all the time after the operation
Sponsors
Capital Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
12 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* pasp\>50mmHg
Exclusion criteria
* pasp\<50mmhg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the simvastatin can alleviate pulmonary hypertension | — |
| pulmonary pressure | — |
Secondary
| Measure | Time frame |
|---|---|
| simvastatin can highten the perioperative and long term survaval rate and the living quality | — |
Countries
China
Contacts
Primary ContactHuili Gan, MD,Ph.D.
Outcome results
None listed