Language in Primary Progressive Aphasia

Asymmetric Neurodegeneration and Language in Primary Progressive Aphasia

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00537004

Enrollment

500

Registered

2007-09-28

Start date

2007-05-01

Completion date

2027-04-01

Last updated

2026-02-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Progressive Aphasia

Keywords

primary progressive aphasia, frontotemporal dementia, semantic dementia, progressive nonfluent aphasia, progressive aphasia, frontotemporal lobar degeneration

Brief summary

The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.

Detailed description

The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies. During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), advanced imaging (MRI and PET), cognitive experiments, and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures. For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Diagnosis of primary progressive aphasia * Right-handed * Native English speaker * Visual acuity of 20/30 corrected * Adequate hearing to follow conversation * Safe for an MRI scan

Exclusion criteria

* Left-handedness * Claustrophobia * Presence of significant medical illness that initially or in the future could interfere with continued participation in the study

Design outcomes

Primary

Measure	Time frame
Neuropsychological variables	Immediately after testing and at two years post-testing

Countries

United States

Contacts

CONTACTElizabeth A Haynes

PPA.Research@northwestern.edu312-503-2398

PRINCIPAL_INVESTIGATORMarsel Mesulam, MD

Northwestern University Feinberg School of Medicine

Outcome results