Lymphoma, Low-Grade
Conditions
Keywords
localized low grade lymphoma, Chemotherapy, Radiotherapy, Molecular analyses, primary
Brief summary
To compare localiezd radiotherapy to localized radiotherapy followed by 6 cycles of chemotherapy in the treatment of localiezd low grade lymphoma
Detailed description
The standard treatment ol localized low grade lymphomas is Radiotherapy alone can offer long term remissions to some patients . No study have clearly demonstrated the interest of chemotherapy. The purpose of the study is to determine wether prednisone administrated after first line local radiotherapy (30 GY) can pre in the treatment of localized low grade lymphomas of adult patients
Interventions
PROCEDUREradiotherapy
mini chep+ radiotherapy
DRUGMINI CHEP
chemotherapy minichep 6 courses
Sponsors
French Innovative Leukemia Organisation
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Low grade lymphoma defined according to the Ann Arbor classification * localized
Exclusion criteria
* Subjects unable to signed informed consent * Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| failure free survival at 5 years | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| overall survival at 5 years | 5 years |
| response rates at the end of the treatment | 6 months |
| prognstic value of molecular analyses in blood and marrow | 6 months |
Countries
France
Outcome results
None listed