Hemostasis
Conditions
Keywords
platelet, aggregation, aspirin
Brief summary
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
Detailed description
An in vivo study on healthy volunteers with combinations of well established drugs
Interventions
DRUGAcetylsalicylic acid, acetaminophen, diclofenac, naproxen, placebo
1. Acetylsalicylic acid 100mg/po and acetaminophen 3x1g/po for 4 days 2. Acetylsalicylic acid 100mg/po and diclofenac 3x50mg/po for 4 days 3. Acetylsalicylic acid 100mg/po and naproxen 3x250mg/po for 4 days 4. Acetylsalicylic acid 100mg/po and placebo 3x1/po for 4 days
Sponsors
Kantonsspital Graubünden
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers
Exclusion criteria
* Administration of drugs affecting platelets * History of bleeding * Gastrointestinal disorders * Hypersensitivity to aspirin and/or NSAID * Pregnancy and breast feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| platelet aggregation | 5 days |
Countries
Switzerland
Outcome results
None listed