Anesthetics and Auditory, Visceral, and Heat Evoked Potentials

Influence of Anesthetics on Sedation and Antinociception: an Analysis of Auditory Evoked, Visceral Evoked and Heat Evoked Potentials

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00534586

Enrollment

Registered

2007-09-26

Start date

2005-12-31

Completion date

2007-05-31

Last updated

2007-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Pain, SSEP, CHEPS, Propofol, Sevoflurane, S-Ketamine, Remifentanil, Healthy volunteers

Brief summary

The aim of the present study is to investigate and quantify the influence of commonly used anesthetics on auditory and pain evoked potentials.

Detailed description

During surgery patients are exposed to different auditory and sensory stimuli. In this study we investigate the influence of different anesthetics to alertness and nociception. In addition to auditory stimuli (AEP as a measure of sedation), Contact Heat Evoked Potential Stimuli (CHEPS), and esophageal evoked potentials from the lower 1/3 of the esophagus are measured to quantify the effects of anesthetics. 60 Volunteers are enrolled into this study. For each drug, three different levels are measured: * level 1 no medication * level 2 low dose of medication * level 3 light sedation dose (volunteer responds to command) Four drugs are measured in the study: propofol, sevoflurane, S-ketamine and remifentanil.

Interventions

DRUGPropofol

TCI 0.5 mcg/ml 1.0 mcg/ml

DRUGRemifentanil

continuous infusion 0.05 mcg/kg/min 0.15 mcg/kg/min

DRUGS-Ketamine

continuous infusion 0.25 mg/kg/h 0.50 mg/kg/h

DRUGSevoflurane

via face mask 0.40 Vol% 0.80 Vol%

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* American Society of Anesthesiologists (ASA) physical status 1-2

Exclusion criteria

* drugs that effect the central nervous system * neurological or psychiatric diseases * contraindications against propofol, sevoflurane, S-ketamine or remifentanil * any damages or loss of hearing * heartburn or any stomach diseases

Design outcomes

Primary

Measure	Time frame
influence of different drugs on evoked responses	2 hours

Secondary

Measure	Time frame
discrimination of antinociceptive, visceral-perceptive and sedative effects of anesthetics	2 hours
quantification of anesthetic components of propofol, sevoflurane, S-ketamine and remifentanil	2 hours

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026