Age-Related Macular Degeneration
Conditions
Keywords
age-related macular degeneration, genetics
Brief summary
The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals. Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.
Interventions
PROCEDUREdrawing blood
Sponsors
Rudolf Foundation Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* man and women over 18 years old * Filled out informed consentBereitschaft zur Teilnahme * Diagnosis of non-exudative/ exudative age related macular dgeneneration
Exclusion criteria
* inherited retinal diseases * other aquired retinal/ macular * missing informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals | — |
Secondary
| Measure | Time frame |
|---|---|
| a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD | — |
Countries
Austria
Outcome results
None listed