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Effect of Donepezil on the Reorganization of Cognitive Neural Network in Patients With Post-Stroke Cognitive Impairment

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00530478
Enrollment
Unknown
Registered
2007-09-17
Start date
Unknown
Completion date
Unknown
Last updated
2007-09-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

Donepezil, Stroke, Cognitive function, Cognitive neural network

Brief summary

The purpose of this study is to demonstrate the efficacy and safety of donepezil on the recovery of cognitive function in patients with stroke and to delineate the neurophysiologic mechanisms of the therapeutic effect of donepezil on the recovery of cognitive network using functional neuroimaging technique.

Interventions

DRUGDonepezil

Sponsors

Samsung Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
16 Years to 80 Years

Inclusion criteria

* Ischemic stroke in the territory of right or left middle cerebral artery * Post-onset duration of the recent-onset stroke is over 3 months * Cognitive deficit ranged from 10 to 26 by minimal mental status examination (MMSE) score * Disturbance in activities of daily living (ADL) ranged 0.5 \ 2.0 by clinical dementia rating (CDR) scale

Exclusion criteria

* Severe internal carotid artery stenosis on the lesion side * Cardiac pacemaker or intracranial metal insertion * Post-stroke seizure disorder or any evidence of epileptic spikes on electroencephalography (EEG)

Countries

South Korea

Contacts

Primary ContactYun-Hee Kim, MD, PHD
yunkim@smc.samsung.co.kr82-2-3410-2818

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026