Mechanical Ventilation
Conditions
Brief summary
Neurally adjusted ventilatory assist (NAVA) is a new concept of mechanical ventilation. NAVA delivers assist to spontaneous breathing based on the detection of the electrical activity of the diaphragm. We study the effect of changing ventilatory parameters on the patient's breathing pattern during NAVA.
Interventions
assessment of breathing pattern at various ventilator settings
Sponsors
Insel Gruppe AG, University Hospital Bern
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Invasive mechanical ventilation (tracheally intubated or tracheotomized) * Presence of an arterial pressure line. * Subject itself or its next of kin has given written informed consent
Exclusion criteria
* Patient is less than 18 years or more than 85 years of age * The attending physician refuses to allow enrollment * The patient refuses informed consent * Next of kin is unavailable or refuses informed consent * Pregnant or breast-feeding female. A pregnancy test will be performed in all female patients less than 60 years of age. * Any contraindication to insertion/exchange a nasogastric tube, including (but not limited to): severe oropharyngeal malformation or bleeding; esophageal varices, tumor, infection, stenosis, or rupture * Presence or suspicion of diaphragm injury * Hemophilia or other severe bleeding disorder * Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection * History of heart and/or lung transplantation * Any mechanical cardiac assist device (excluding intraaortic balloon pump) * Any contraindication to reduce sedation or to stop neuromuscular blockage in order to allow spontaneous breathing * The patient needs to be ventilated with a mode of mechanical ventilation that targets a predefined tidal volume or airway pressure as per attending physician * Severe hemodynamic instability as per attending physician * Planned or anticipated intervention within the study period necessitating either transfer out of the ICU or requiring prolonged interaction with the patient. * A fraction of inspired oxygen (FiO2) of \> 0.8 * The patient currently participates in another interventional clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in diaphragmatic Edi (area under the curve) during expiration | At each intervention |
Countries
Switzerland
Outcome results
None listed