Ductus Arteriosus, Patent, Infant, Premature, Natriuretic Peptide Brain
Conditions
Keywords
preterm infants < 28 weeks, B-type natriuretic peptide, prediction, ductus intervention
Brief summary
The aim of the study was to evaluate BNP in preterm infants \< 28 weeks on the second day of life, when it is still unknown, if a patent ductus arteriosus is hemodynamic significant or not. We hypothesized that high plasma BNP concentrations on day 2 are associated with the need of PDA intervention in the further course.
Detailed description
From the study infants blood samples (0.1ml) were collected in K-EDTA microtubes within 24 to 48 hours of age through umbilical artery catheter aspiration or routine venous puncture. The samples were spun at 7000 rpm for 3 minutes. Platelet-free plasma was stored at -20°C until BNP analysis of all collected samples was carried out. The BNP assay was performed using a fully automated immunoassay system ADVIA method for the Centaur System (Bayer Diagnostic Division). In preterm infants who were treated with indomethacin or surgical ligation we collected additional blood samples 2-4 hours before intervention and 24 hours after the completion of the ductus treatment.
Interventions
None listed
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
DEFINED_POPULATION
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
24 Hours to 48 Hours
Healthy volunteers
No
Inclusion criteria
* Written parental informed consent * Preterm infant \< 28 weeks of gestation * Admitted to our NICU within 48 hours after birth
Exclusion criteria
* No written parental informed consent, * Congenital heart disease, * Death
Countries
Germany
Outcome results
None listed