Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation

Prospective Study Comparing Hyperbilirubinemia, CRP, White Blood Cell Count, and Other Clinical Parameters for the Preoperative Diagnosis of Perforated Acute Appendicitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00528138

Enrollment

132

Registered

2007-09-12

Start date

2007-10-31

Completion date

2008-09-30

Last updated

2009-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perforated Appendicitis

Keywords

Appendicitis, Hyperbilirubinemia, CRP, Values of bilirubin, Values of liver function test, Values of white blood cells, Values of CRP

Brief summary

It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis. The investigators believe, based on their own previous publications, that C-reactive protein (CRP) with or without a white blood cell count and some other clinical parameters, are more specific markers for the preoperative diagnosis of perforated acute appendicitis. The purpose of this study is to prospectively compare the specificity and sensitivity of hyperbilirubinemia CRP, white blood cell count and other clinical parameters for the preoperative diagnosis of acute appendicitis.

Detailed description

* Previously validated appendicitis score * Time from onset of symptoms to diagnosis and to surgery * Laboratory values: WBC, CRP, liver function test * SIRS values * Preoperative and postoperative diagnosis * Length of hospital stay * Postoperative complications * Biopsy results

Interventions

OTHERLaboratory Test

CRP, white blood cell count, hepatic function tests

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

15 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients scheduled for appendectomies for acute appendicitis at the emergency unit of our institution * Patients older than 15 years of age to 100 years of age

Exclusion criteria

* Appendectomy performed incidentally or for other indications * Patients younger than 15 years of age * Alcoholism * A history of viral hepatitis * Gilbert's disease * Dubin Johnson syndrome * BRIC (benign recurrent intra-hepatic cholestasis) and other documented biliary * Hemolytic or liver diseases associated with hyperbilirubinaemia

Countries

Chile

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026