Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion

Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00526695

Enrollment

Registered

2007-09-10

Start date

2005-01-31

Completion date

2008-12-31

Last updated

2008-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemia/Reperfusion Injury

Keywords

Ischemia/Reperfusion, Organ Protection, Anesthetics

Brief summary

Sevoflurane preconditioning and cardiovascular protection against ischemia/reperfusion injury. Study hypothesis: The volatile anesthetic sevoflurane at subanesthetic concentrations achieves endothelial protection against ischemia/reperfusion injury and reduces inflammatory markers in the circulation

Detailed description

Healthy volunteers are included in the study to investigate endothelial function and platelet activation after preconditioning by sevoflurane in subanesthetic concentrations. Forearm perfusion, endothelial function and leukocyte/thrombocyte activation after tourniquet-induced ischemia/reperfusion injury of the forearm are measured using healthy volunteers in a cross-over design.

Interventions

DRUGSevoflurane (Preconditioning)

Inhalation of sub-anesthetic doses of sevoflurane

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

25 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

male * Non-smoker * No asthma * NPO * Volunteer

Exclusion criteria

* Female * Chronic medication * Asthma * Smoking

Design outcomes

Primary

Measure	Time frame
marker expression on blood cells	December 2008

Countries

Switzerland

Contacts

Primary Contact01 Studienregister MasterAdmins

+41 (0)44 255 11 11

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026