Cancer, Pain, Palliative Care
Conditions
Keywords
Cancer Pain, Methadone, Morphine, Acetaminophen, Palliative Care
Brief summary
The purpose of this study is to determine whether oral methadone plus acetaminophen can substitute morphine in the treatment of cancer pain.
Detailed description
Opioids are the mainstay of moderate-to-severe cancer pain management. Although morphine is the most commonly used, methadone has some advantages such as higher potency, lower cost and longer administration intervals. To minimize the time necessary to achieve the equianalgesic effect after a switching from morphine to methadone, acetaminophen was added in the treatment.
Interventions
DRUGMethadone plus Acetaminophen or Placebo
Methadone bid according to a established conversion morphine-to-methadone ratio plus Placebo or Acetaminophen qid
Sponsors
Faculdade de Medicina do ABC
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of cancer pain * Regular use of oral Morphine
Exclusion criteria
* Use of Acetaminophen in the last 48 hours * Renal or Hepatic failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity and time to equianalgesic effect | within the first 7 days after switching |
Secondary
| Measure | Time frame |
|---|---|
| Degree of nausea, vomiting, obstipation, xerostomia and drowsiness | within the first 7 days of switching |
Countries
Brazil
Contacts
Primary ContactDaniel IG Cubero, MD
Outcome results
None listed