Zero Calorie Drink Products

Determination of Clinically Significant Carbohydrates Added to Zero Calorie Drink Products

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00525694

Acronym

GGT

Enrollment

Registered

2007-09-06

Start date

2007-02-28

Completion date

2010-11-30

Last updated

2016-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Brief summary

This will be a clinical test to determine if any carbohydrate or a gluconeogenic precursor added to a zero calorie product might be important to consider in the management of obesity, metabolic syndrome and diabetes mellitus. This research trial will evaluate the effect of three different solutions on blood glucose level. One solution is plain water, the second a standard high glucose (sugar) solution used typically in diabetes testing, and the third a low calorie drink (Zero Coke). Based on a prior study evaluating a diet for effective weight loss, we observed that patients who drank large volumes of diet soda did not lose weight as readily as those who did not drink diet soda. Therefore, we propose to examine the actual effect of one diet soda (Zero Coke) on the body's glucose level and compare it to water and a high glucose solution. All participants in this study must have 3 Glucose tolerance evaluations - one with each solution: water, high glucose, and Zero Coke.

Interventions

OTHERGlucose tolerance test

10 ounces glucose tolerance test solution

OTHERglucose tolerance test solution

75 grams glucose load

OTHERDiet Coke

10 ounces of Diet Coke

OTHERCoke Zero

10 ounces of Coke Zero

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* healthy, * asymptomatic individuals for diabetes and pre-diabetes, * especially for people at high risk of developing diabetes, * such as those with a family history of diabetes, * those who are overweight, * and those who are more than 40 to 45 years old

Exclusion criteria

* Patients with chronic illnesses, especially diabetes

Design outcomes

Primary

Measure	Time frame
to determine if any carbohydrate or a gluconeogenic precursor added to a zero calorie product might be important to consider in the management of obesity, metabolic syndrome and diabetes mellitus.	3 days

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026