How to Improve Diagnosis in Infective Endocarditis

Ph. D Student, Jane Byriel Knudsen, Aarhus University

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00524212

Enrollment

761

Registered

2007-09-03

Start date

2007-03-31

Completion date

2009-05-31

Last updated

2010-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endocarditis, Bacterial

Brief summary

The purpose is to exam prospective if simple clinical information in combination with a normal s-procalcitonin are sufficient for exclusion of infective endocarditis (IE).

Detailed description

Despite progress in surgical and medical treatment, infective endocarditis is still associated with high morbidity and mortality. The variable clinical presentation of IE makes the diagnosis a clinical challenge. Procalcitonin is a precursor from the hormone calcitonin and also a marker of systemic bacterial infections. The purpose of this study is: * to investigate the diagnostic value of serum procalcitonin (PCT), C-reactive protein (CRP) and sedimentation rate (SR) when IE is suspected. * to investigate if a retrospectively generated clinical model suitable for exclusion of IE can be confirmed prospectively.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients \> or = 18 year with suspected or verified Infective Endocarditis * By word of mouth or in writing consent

Exclusion criteria

* Incapacity

Countries

Denmark

Outcome results