Tuberculous Pleurisy
Conditions
Keywords
loculated pleural effusion, pigtail drainage, pleural effusion, pleural thickening, tuberculosis
Brief summary
Tuberculous (TB) pleurisy can cause clinical symptoms and pleural fibrosis with resultant residual pleural thickening (RPT). Therapeutic thoracentesis or initial complete drainage in addition to anti-TB drugs have been tried to rapidly relieve dyspnea caused by effusion and to decrease the occurrence of RPT. However, contradictory results are reported without clear reasons. The researchers' hypothesis is that, in addition to anti-TB medications, early effective evacuation of inflammatory exudates with or without fibrinolytic agents may hasten resolution of pleural effusion, reduce the occurrence of RPT and finally improve long-term functional outcome in patients with TB pleurisy.
Interventions
PROCEDUREPigtail drainage
Sponsors
Taipei Medical University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of tuberculous pleurisy
Exclusion criteria
* History of invasive procedures directed into the pleural cavity * Recent severe trauma, hemorrhage, or stroke; bleeding disorder or anticoagulant therapy * Use of streptokinase in the previous 2 years * Lack of clinical symptoms caused by effusions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chest radiography, daily monitoring of the volume of fluid drained, the time needed for resolution of fever and dyspnea, and total amounts of fluid drained, and the length of chest drainage and hospitalization | baseline, daily after treatment within admission |
Secondary
| Measure | Time frame |
|---|---|
| Chest radiography and pulmonary function testing with spirometry | At discharge and at 2, 4, 6, and 12 months |
Countries
Taiwan
Outcome results
None listed