Coronary Artery Disease, Depression
Conditions
Brief summary
Patients recovering from coronary artery bypass graft (CABG) surgery have high rates of depression, and depression is associated with higher risk of complications and death. Recent discoveries show that depression involves changes in certain molecules in the blood, which are also involved in progressive coronary artery disease (CAD) and its complications. This study will evaluate the effects of cognitive behavioral therapy (CBT) as a treatment for depression on these biological markers among CABG patients.
Interventions
BEHAVIORALCognitive Behavioral Therapy (CBT)
Subjects receive CBT in the home for 8 weeks with blood draws every other week during therapy.
BEHAVIORALUsual Care
Subjects receive Usual Care for 8 weeks followed by CBT
Sponsors
National Institute of Nursing Research (NINR)
University of California, Los Angeles
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
45 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Undergone CABG at one of our recruitment sites
Exclusion criteria
* Less than 45 years of age * Have cognitive impairment or major comorbid psychiatric conditions * Have autoimmune disorder or malignancy * Currently smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of proinflammatory cytokines (IL-1 and IL-6) | at baseline and after 8 weeks (at the completion of the intervention) |
| The soluble receptor for IL-6 (sIL-6) | at baseline and after 8 weeks (at the completion of the intervention) |
| Inflammatory markers c-reactive protein (CRP and sICAM-1) | at baseline and after 8 weeks (at the completion of the intervention) |
Secondary
| Measure | Time frame |
|---|---|
| Depression symptoms (Beck Depression Inventory) | at baseline and after 8 weeks (at the completion of the intervention) |
| Sleep disturbances | at baseline and after 8 weeks (at the completion of the intervention) |
| Presence of clinical depression | at baseline and after 8 weeks (at the completion of the intervention) |
| Pain | at baseline and after 8 weeks (at the completion of the intervention) |
Countries
United States
Outcome results
None listed