Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00522496

Enrollment

Registered

2007-08-29

Start date

2007-07-31

Completion date

2009-08-31

Last updated

2009-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Injuries, Traumatic

Keywords

Craniocerebral trauma, matrix metalloproteinase, microdialysis

Brief summary

The purpose of this study is to: 1. Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury 2. Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury 3. Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient is 18 years of age or older * Patient has GCS less than 9 * Patient requires intracranial pressure monitoring * Patient life expectancy greater than 72 hours

Exclusion criteria

* Patient's TBI is greater than 24 hours old * Patient is less than 18 years of age * Patient does not require intracranial pressure monitoring * Patient has life expectancy less than 72 hours * Patient has GCS greater or equal to 9 * Patient is currently enrolled in another study

Countries

Canada

Contacts

Primary ContactDavid A Zygun, MD

dzygun@ucalgary.ca403-944-1691

Outcome results