Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Trial

Conditions

Primary Hyperparathyroidism

Keywords

QoL, Osteodensitometry, Arterial pressure, PTH

Brief summary

The present study is a randomized, controlled trial that investigates the effects of parathyroidectomy or medical observation in mild asymptomatic pHPT on morbidity and quality of life (QoL).

Detailed description

The patients are included and randomized by block randomization to medical observation or parathyroidectomy by an experienced parathyroid surgeon. The patients will be followed up for 10 years.

Ansgar Heck, Mikkel Pretorius, Karolina Lundstam, Kristin Godang, Mikael Hellström et al. (7 authors)

European Journal of Endocrinology2024-08-246 citations

10.1093/ejendo/lvae109

Mortality and Morbidity in Mild Primary Hyperparathyroidism: Results From a 10-Year Prospective Randomized Controlled Trial of Parathyroidectomy Versus Observation.

Pretorius M, Lundstam K, Heck A, Fagerland MW, Godang K, Mollerup C, Fougner SL, Pernow Y, Aas T, Hessman O, Rosén T, Nordenström J, Jansson S, Hellström M, Bollerslev J.

2022-04-1930 citations

10.7326/m21-4416

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to 80 Years

Healthy volunteers

No

Inclusion criteria

* Untreated, asymptomatic pHPT * 2.60\>S-Ca\<2.85 mmol/liter * Age between 50 and 80 yr * No medications interfering with Ca-metabolism * Informed consent

Exclusion criteria

* Hyperparathyroid bone disease * Previous operation in the neck * Impaired kidney function * Kidney stones * Complicating medical conditions * Psychiatric disorders * Multiple endocrine neoplasia, * Familial hypocalcuric hypercalcemia * Familial HPT

Countries

Norway

Outcome results