Glomerulonephritis, IGA
Conditions
Keywords
IgA, kidney, Berger'disease, regulatory T cells, pathogenesis of Berger's disease
Brief summary
Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental in suppressing adaptative immune responses, including B cells production of immunoglobulins. We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.
Interventions
PROCEDUREgene transcription and cytometry
samply of 30 ml of blood
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with pathogenesis of Berger's disease confirmed by renal biopsy * Glomerular filtration \> 60 ml/min/1,73m2 * Written informed consent * Patient affiliated to social insurance
Exclusion criteria
* Immunosuppressor treatment within 6 months before the study inclusion * Clinical infection within 2 months before the study inclusion * C-reactive protein (CRP) \> 10 mgL-1
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion averages of cells CD4+CD25+CD127 low T in peripheral blood | inclusion |
Secondary
| Measure | Time frame |
|---|---|
| average relative expression of genes FoxP3, CTLA4, GITR, IL10, TGF-B, OX40, TIM-1, and TIM-3 | inclusion |
Countries
France
Outcome results
None listed