Diabetes Mellitus, Type 2
Conditions
Keywords
cardiovascular disease, glucose intolerance, type 2 diabetes, endothelial dysfunction, inflammation, Age> 30 years, male and female, Fasting glucose below 126 mg/dl
Brief summary
The study aims to evaluate IFG, IGT or unknown type 2 diabetes mellitus in new classes at high risk to develop alterations of glucose metabolism and definition of new pathogenic mechanisms of insulin resistance and atherosclerosis. The following classes of subjects at high risk will be considered:First degree relatives of patients with type 2 diabetes mellitus, patients with cardiovascular disease and stroke, patients with heart valve disease. age will be \> 30 years, both gender.
Detailed description
The primary outcome of the study is evaluation of glucose tolerance, insulin sensitivity and insulin secretion before and 2 hours post-glucose load Secondary outcomes are evaluation of endothelial function, of natriuretic peptides and free fatty acids, and inflammation before and 2 hours post-glucose load. New candidate genes will be also evaluated.
Interventions
None listed
Sponsors
IRCCS San Raffaele
Study design
Observational model
DEFINED_POPULATION
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
30 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Fasting glucose levels \<126 mg/dl * Age \>30 years * Both male and female
Exclusion criteria
* Type 1 diabetes * Known type 2 diabetes mellitus * Pregnancy * Impaired kidney and liver function * Previous history of malignancies
Countries
Italy
Outcome results
None listed