Systemic Lupus Erythematosus
Conditions
Keywords
Systemic Lupus Erythematosus, Estrogen receptors, T cells, Hormones, Female adult SLE
Brief summary
This study involves research to investigate how estrogen affects women of childbearing age and its correlation to Systemic Lupus Erythematosus. The findings from this study might help determine how body cells, called T Cells, react to estrogen. The study will seek to determine if cells from women with Lupus, react differently from cells in persons without Lupus. We will attempt to identify genetic factors that determine the effects of estrogen on Lupus cells.
Detailed description
This is a 3-year study. The total number of subjects enrolled will depend on the results obtained. The subjects will be at least 18 years of age and pre-menopausal. Exclusion to include pregnant women, and all subjects are told not to get pregnant while on study. Also, they cannot take hormones by mouth or patch while on study. The study can include healthy subjects as well. Blood will be drawn (120 ml) four times a year, randomly.
Interventions
OTHERPeripheral lab draws
100ml blood for analysis, taken no more than 4 times in one year.
Sponsors
AstraZeneca
The Center for Rheumatic Disease, Allergy, & Immunology
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* female subjects with Lupus, and female subjects without Lupus. age at least 18, not pregnant and not planning to get pregnant.
Exclusion criteria
* Pregnant or planning to get pregnant. On hormone replacement, or birth control of any kind.
Countries
United States
Contacts
Primary ContactNabih I Abdou, MD, PhD.
Backup ContactCindy Greenwell, RN
Outcome results
None listed