Sepsis, Systemic Inflammatory Response Syndrome
Conditions
Keywords
SIRS, sepsis and related syndromes
Brief summary
Patients undergoing major surgery, trauma or burns are prone to develop an exacerbated inflammatory response, which is potentially lethal to the individual. Recently, the researchers' group showed in a rodent model of hemorrhagic shock that high-fat feeding administered before shock attenuates inflammation and reduces intestinal and hepatic damage. In the mechanism that underlies this protective effect, the release of cholecystokinin in gut wall and activation of efferent vagus bundles are crucial events. Before investigating the effect of high-fat nutrition in clinical setting, suitable markers of inflammation and organ damage need to be selected. In this study, blood will be collected in patients undergoing different types of operations. Consequently several markers for inflammation and organ damage will be determined. Hence, suitable parameters for a future high-fat intervention study will be selected.
Interventions
PROCEDUREBlood collection
In arterial or venous lines already present, small amounts of blood will be collected at certain timepoints following operation
Sponsors
Maastricht University Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* \> 18 years * elective liver / colon / femur surgery
Exclusion criteria
* Acute inflammation * Chronic Obstructive Respiratory Disease * Recent history of abdominal pain or diarrhea * BMI \< 18.5 * Alcohol or Drugs abuses * Recent intake of antibiotics
Countries
Netherlands
Outcome results
None listed