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Organ Protection With Sevoflurane Postconditioning

Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion: Postconditioning

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00518908
Enrollment
125
Registered
2007-08-21
Start date
2008-01-31
Completion date
2010-09-30
Last updated
2011-07-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatectomy

Keywords

Ischemia reperfusion injury, Organ protection

Brief summary

Organ protection, volatile anesthetics, postconditioning, hepatic surgery

Detailed description

This study aims at the evaluation of a potential attenuation of ischemic-reperfusion injury in the liver with sevoflurane postconditioning upon reperfusion.

Interventions

DRUGSevoflurane

3.2 Vol % for postconditioning

Sponsors

University of Zurich
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* older than 18 years * patients undergoing liver resection (benign or malignant tumors)

Exclusion criteria

* non-german speakers * laparoscopic liver resection * coagulopathy (platelets \< 50'000/ml, Quick \< 50%) * liver cirrhosis

Design outcomes

Primary

MeasureTime frameDescription
Liver transaminase ASTPostoperative phase until dischargePeak value

Secondary

MeasureTime frame
ALT peak valuePostoperative phase until discharge
Course of transaminasesFrom the day before surgery, to 6 hours after surgery, up to postoperative day 7
Postoperative complicationsPostoperative phase until discharge
Length of hospital stayPostoperative phase until discharge
Need for prolonged intensive care unit stay (>24 hours)Postoperative phase until discharge

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026