Parkinson's Disease
Conditions
Keywords
Parkinson's Disease, Magnetic Resonance Imaging (MRI), neuropsychological assessment
Brief summary
The purpose of this study is to investigate similarities and differences in the neural pathways of depressed Parkinson's patients, non-depressed Parkinson's patients, and healthy controls using magnetic resonance imaging (MRI) of the brain and neuropsychological assessment.
Detailed description
Depression is a common and potentially serious complication of Parkinson's disease (PD). Studies show that approximately 40 percent of PD patients are depressed. There is evidence that these patients have deficits in neuropsychological function relative to non-depressed PD patients. Despite the widespread toll on emotional health posed by PD, few studies have undertaken a comprehensive examination of the neural underpinnings of Parkinsonian depression. In this project, we will compare depressed versus non-depressed Parkinson patients to a sample of demographically-matched healthy controls using neuropsychological assessment and magnetic resonance imaging (MRI). To investigate possible effects of anti-Parkinsonian medication on mood, cognitive function, and neural response, PD patients will be tested both off and on Parkinsonian medications.
Interventions
None listed
Sponsors
National Institute of Mental Health (NIMH)
National Institute of Neurological Disorders and Stroke (NINDS)
Lee Blonder
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* right-handed * willing/able to undergo magnetic resonance imaging (MRI)
Exclusion criteria
* history of neurological condition other than Parkinson's disease * history of psychiatric condition other than depression * history of substance abuse/dependence
Countries
United States
Outcome results
None listed