The Finnish Diabetes Prevention Study

Conditions

Type 2 Diabetes

Keywords

Type 2 diabetes, primary prevention, diet, physical activity, intervention, impaired glucose tolerance, lifestyle, randomized controlled study

Brief summary

The aim of this study is to clarify whether lifestyle intervention provided to people with high type 2 diabetes risk will lower the cumulative incidence of diabetes. Furthermore, the aim is to study the effect of lifestyle intervention on cardiovascular risk.

Moustafa M. A. Ibrahim, Matti Uusitupa, Jaakko Tuomilehto, Jaana Lindström, Maria C. Kjellsson et al. (6 authors)

CPT Pharmacometrics & Systems Pharmacology2025-06-303 citations

10.1002/psp4.70065

Importance of weight loss maintenance and risk prediction in the prevention of type 2 diabetes: analysis of European Diabetes Prevention Study RCT.

Penn L, White M, Lindström J, den Boer AT, Blaak E, Eriksson JG, Feskens E, Ilanne-Parikka P, Keinänen-Kiukaanniemi SM, Walker M, Mathers JC, Uusitupa M, Tuomilehto J.

2013-02-2590 citations

10.1371/journal.pone.0057143

Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study.

Siitonen N, Pulkkinen L, Lindström J, Kolehmainen M, Schwab U, Eriksson JG, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M.

2011-09-2422 citations

10.1186/1475-2840-10-83

Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.

Siitonen N, Pulkkinen L, Lindström J, Kolehmainen M, Eriksson JG, Venojärvi M, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M.

2011-01-10117 citations

10.1186/1471-2350-12-5

Ten-year mortality and cardiovascular morbidity in the Finnish Diabetes Prevention Study--secondary analysis of the randomized trial.

Uusitupa M, Peltonen M, Lindström J, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Valle TT, Eriksson JG, Tuomilehto J, Finnish Diabetes Prevention Study Group.

2009-05-21135 citations

10.1371/journal.pone.0005656

Interventions

BEHAVIORALIntensive lifestyle counselling

Individualized dietary and physical activity counselling aiming at 1. weight reduction 2. dietary fibre 15 g /1000 kcal or more 3. energy proportion of dietary fat less than 30% 4. energy proportion of saturated fat less than 10% 5. moderate physical activity \>30 minutes per day or 4 hours per week

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* impaired glucose tolerance (p-glucose 2 hours after a 75 g oral glucose load between 7.8 and 11.0 mmol/l) * body mass index 25 or higher

Exclusion criteria

* diabetes (previous gestational diabetes accepted) * other chronic disease rendering survival for 6 years * condition or medication affecting glucose tolerance * recent myocardial infarction

Design outcomes

Primary

Measure	Time frame
Diabetes incidence	During the intervention period + after the intervention has been stopped

Secondary

Measure	Time frame
CVD incidence	During the total follow up

Countries

Finland

Outcome results

None listed