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Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure

Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure: Effects on Exercise Capacity and Hypoxia, Chemoreceptor Response, Pulmonary Function

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00517725
Acronym
CARNEBI
Enrollment
60
Registered
2007-08-17
Start date
2007-07-31
Completion date
2010-05-31
Last updated
2010-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Heart Failure

Keywords

exercise, lung diffusion, hypoxia, chemoreceptor, beta-blockers, heart failure

Brief summary

The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity. Both could influence exercise capacity in normoxic as well as hypoxic conditions.

Interventions

DRUGcarvedilol
DRUGbisoprolol
DRUGNebivolol

Sponsors

Centro Cardiologico Monzino
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* Chronic heart failure patients in stable clinical condition

Exclusion criteria

* No comorbidity * NYHA class IV

Design outcomes

Primary

MeasureTime frame
exercise capacitytwo months

Secondary

MeasureTime frame
lung diffusiontwo months

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026