Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00517322

Enrollment

Registered

2007-08-16

Start date

2007-08-31

Completion date

2010-08-31

Last updated

2007-08-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antihypertensive Drugs, Diastolic Function, Hypertensive Heart Disease, Left Atrial Volume, Renin Angiotensin System

Keywords

left atrial volume, hypertension, ramipril, irbesartan, diastolic function

Brief summary

Aim of the study is to compare in hypertensive patients the effect of one year therapy with ACE-inhibitor (RAMIPRIL) or angiotensin II receptor blocker (IRBESARTAN) on left atrial remodelling and diastolic function.

Interventions

DRUGramipril

ramipril 2.5- 5 mg once daily

DRUGirbesartan

irbesartan 150-300 mg once daily

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

40 Years to 65 Years

Healthy volunteers

Inclusion criteria

· * mild to moderate essential hypertension * no antihypertensive treatment * good quality echocardiogram

Exclusion criteria

* cardiovascular diseases (AMI, stroke o TIA) * heart failure, valvular heart disease * diabetes * secondary hypertension * atrial fibrillation * hepatic and renal severe failure * pregnancy

Design outcomes

Primary

Measure	Time frame
left atrial volume	one year
diastolic function	one year

Secondary

Measure	Time frame
systolic and diastolic blood pressure	one year

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026